CCL22 is a potential bio-marker for osteoarthritic pain and cartilage degeneration

Cartilage in osteoarthritic joints is not automatically osteoarthritic cartilage.

Ion channels and osteoarthritic pain: potential for novel analgesics.

Osteoarthritis (OA) is a debilitating chronic condition widely prevalent in ageing populations. Because the pathology of the disease includes cartilage erosion and joint remodelling, OA patients experience a great deal of pain. Despite numerous studies, details of OA are frequently inseparable from other types of chronic pain, and its causes are unknown. In most circumstances in OA, the cartila...

An In Vivo Lapine Model for Impact-Induced Injury and Osteoarthritic Degeneration of Articular Cartilage

OBJECTIVE In this study, we applied a spring-loaded impactor to deliver traumatic forces to articular cartilage in vivo. Based on our recent finding that a 0.28-J impact induces maximal catabolic response in adult bovine articular cartilage in vitro using this device, we hypothesize that this impact will induce the formation of a focal osteoarthritic defect in vivo. DESIGN The femoral condyle...

A Method to Monitor Local Changes in MR Signal Intensity in Articular Cartilage: A Potential Marker for Cartilage Degeneration in Osteoarthritis

Osteoarthritis (OA) involves changes in the composition and ultimately the loss of cartilage from articulating joints. MRI has the ability to non-invasively probe the compositional integrity of cartilage, thereby potentially identifying diseased cartilage before loss occurs. In this study we have developed a technique to compare local changes in signal intensity over time in fat suppressed 3D g...

Managing osteoarthritic knee pain.

Osteoarthritis is one of the most common forms of arthritis seen in primary care practice. Pain associated with this condition is the chief complaint of most patients, prompting them to seek medical attention. Pain can originate from the synovial membrane, joint capsule, periarticular muscles and ligaments, and periosteum and subchondral bone, among other sources. Although osteoarthritis is tra...